What causes the difference in synergistic potentials of propiconazole and prochloraz toward pyrethroids in Daphnia magna?

•Toxicity of azole fungicides is driven by toxicokinetics (hydrophobicity).•The synergistic potential of azole fungicides is based on their toxicodynamic properties.•The inhibition potential of prochloraz toward in vivo cytochrome P450 (ECOD) activity is approximately 450 times stronger than the inhibition potential of propiconazole.