Whole genome and normalized mRNA sequencing reveal genetic status of TK6, WTK1, and NH32 human B-lymphoblastoid cell lines.

Javier Revollo,Dayton M Petibone,Page B Mckinzie,Bridgett Knox,Suzanne M Morris,Baitang Ning,Vasily N Dobrovolsky

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2016）

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摘要

•Predicted genes, SNPs and mutations in TK6 are similar to the human population.•TK6 (p53wt), WTK1(p53mut) and NH32(p53KO) transcriptomes have not diverged greatly.•NGS identified a mutation in the FTH1 in TK6 that impairs iron metabolism.•SNPs in the TPMT (TPMT*3A SNP), and NQO1 (NQO1*2 SNP) genes impair drug metabolism.•The FTH1 mutation, TPMT*3A and NQO1 SNPs have toxicological and clinical relevance.

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关键词

Next generation sequencing (NGS),p53,FTH1,TPMT*3A,NQO1*2,Human B-lymphoblastoid cells

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