Determination of metabolites of di(2-ethylhexyl) terephthalate (DEHTP) in human urine by HPLC-MS/MS with on-line clean-up.

Frederik Lessmann,André Schütze,Tobias Weiss,Thomas Brüning,Holger M Koch

Journal of Chromatography B（2016）

引用 45|浏览6

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摘要

•We developed a LC–MS/MS method to quantify oxidized monoesters of DEHTP in urine.•Target analytes were chromatographically separated from DEHP metabolite analogues.•Urine samples of the general population were positively tested for target analytes.•Oxidized monoesters are promising biomarkers of exposure for human biomonitoring.

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关键词

Di(2-ethylhexyl) terephthalate,DEHTP,Plasticizer,Exposure assessment,Urinary metabolite,Human biomonitoring

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