The real-life value of ST2 monitoring during heart failure decompensation: impact on long-term readmission and mortality.

Context: Prognostic value of ST2 levels and dynamics has not been investigated in acute heart failure (AHF) using prospective real-life measurements.Objective: The objective of this study is to investigate the prognostic value of ST2 in AHF.Methods: ST2 levels were determined at admission (n=182) and discharge (n=85). Primary endpoint was the composite of all-cause death and HF rehospitalisation at one year.Results: Discharge ST2 (HR 2.42 [95% CI 1.46-4], p=0.001) and ST2 (HR 2.32 [95% CI 1.21-4.57], p=0.01) but not admission ST2, remained independently prognostic for the primary endpoint after comprehensive multivariable adjustment. ST2 significantly improved prognosis stratification on top of clinical variables and NTproBNP.Conclusions: Routine clinical use of discharge ST2 and ST2 dynamics provide independent prognostic information.