Association Of Serum Sparc Level With Severity Of Coronary Artery Lesion In Type 2 Diabetic Patients With Coronary Heart Disease

Objective: To investigate the association of serum SPARC level with the severity of coronary artery lesion in type 2 diabetic patients with coronary heart disease. Methods: 120 patients with type 2 diabetic patients were the subjects. Enzyme- linked immunosorbent assay ( ELISA) was used to detect levels of serum SPARC and Gensini score was used to assess extent of coronary artery lesions. The patients were divided into 4 groups: A group was the healthy control group with 40 patients. According to angiography and the World Health Organization ( WHO) diagnostic criteria for diabetes the rest were divided into B, C, D group: there were 40 cases in group B ( simple type 2 diabetes mellitus group), 40 cases were in group C ( simple CHD group), and 40 cases were in D group ( type 2 diabetes combined with coronary heart disease group). Results: Compared with that in group A, the serum SPARC level in group B, C and D increased significantly ( 4.22 +/- 1.19) mu g/ L, ( 3.71 +/- 1.05) mu g/ L and ( 5.96 +/- 1.40) mu g/ L vs ( 3.60 +/- 0.40) mu g/ L ( P< 0.05). Moreover, the serum SPARC level in group D was the highest ( P< 0.05). Serum SPARC level, insulin resistance ( IR), and glycosylated hemoglobin ( HbA1c) were the vital factors contributing to coronary heart disease. Serum SPARC level was positively correlated with the Gensini scores in group D ( r= 0.770, P< 0.05), whereas it was not related to the Gensini scores in group C ( r= 0.520, P> 0.05). Pearson correlation analysis showed that serum SPARC level was positively correlated with triglyceride, fasting insulin, Homeostasis Model Assessment for Insulin Resistance Index ( r= 0.780, 0.762 and 0.891, respectively; P< 0.05). Conclusion: Serum SPARC level elevated in T2DM patients with coronary heart disease, which was correlated with the severity of coronary artery disease significantly.