Non-invasive topical drug delivery to spinal cord with carboxyl-modified trifunctional copolymer of ethylene oxide and propylene oxide.

Marat I Kamalov,Igor A Lavrov,Abdulla A Yergeshov,Zulfira Y Siraeva,Maxim E Baltin,Albert A Rizvanov,Svetlana V Kuznetcova,Natalia V Petrova,Irina N Savina,Timur I Abdullin

Colloids and Surfaces B: Biointerfaces（2016）

Cited 6|Views11

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Abstract

•Newly synthesized oxidized tri-functional copolymers of ethylene oxide and propylene oxide.•Oxidized copolymers produce uniform micelles resistant to aggregation.•Oxidized copolymers significantly facilitate drug delivery to neural cells and spinal cord from topical gel formulation.

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Key words

Amphiphilic polymers,Trifunctional copolymers of ethylene oxide and propylene oxide,Oxidative modification,Micelles,Drug delivery,Neural cells,Spinal cord,Traumatic injury

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