Polyhalogenated Indoles From The Red Alga Rhodophyllis Membranacea: The First Isolation Of Bromo-Chloro-Iodo Secondary Metabolites
JOURNAL OF NATURAL PRODUCTS(2016)
Abstract
An unusual tetrahalogenated indole with the exceptionally rare inclusion of the three halogens bromine, chlorine, and iodine was found using mass spectrometry within a fraction of a semipurified extract obtained from the red alga Rhodophyllis membranacea. We report herein the isolation and structure elucidation, using a combination of NMR spectroscopy and mass spectrometry, of 11 new tetrahalogenated indoles (1-11), including four bromochloroiodoindoles (5-7, 10). Several were evaluated for cytotoxic and antifiingal activities against the HL-60 promyelocytic cell line and Saccharomyces cerevisiae, respectively.
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Key words
metabolites,bromo-chloro-iodo
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