Overexpression of CSF-1R in nasopharyngeal carcinoma.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie(2015)
Abstract
BACKGROUND:Tumor-associated macrophages play a significant role in tumor progression. CSF-1/CSF-1R is one of the most primary regulators of macrophage physiology in immune system. The expression of CSF-1/CSF-1R in nasopharyngeal carcinoma is unclear.
OBJECTIVES:The aim of this study was to compare the expression of CSF-1R in nasopharyngeal carcinoma to nasopharyngitis for assessing the role CSF-1/CSF-1R in nasopharyngeal carcinoma.
MATERIALS AND METHODS:Diagnostic tissues from 56 nasopharyngeal carcinoma patients and 32 nasopharyngitis patients were evaluated retrospectively by immunohistochemical analysis for the expression of CSF-1R.
RESULTS:Significant differences of CSF-1R expression exists between nasopharyngeal carcinoma patients and nasopharyngitis patients (p<0.001). However, there is no relevance between CSF-1R and worse survival.
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Key words
CSF-1/CSF-1R,nasopharyngeal carcinoma,nasopharyngitis,metastasis,survival
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