Activation of corticotropin-releasing factor neurons and microglia in paraventricular nucleus precipitates visceral hypersensitivity induced by colorectal distension in rats.
Brain, Behavior, and Immunity（2016）
Abstract
•Role of microglia and CRF neurons in PVN on visceral hypersensitivity is unclear.•Inhibition of PVN CRF neurons suppresses visceral hypersensitivity in rats.•Visceral hypersensitivity is related to microglial and TLR4 signaling hyperactivity.•Microglial inhibition suppresses CRF neuronal and visceral hypersensitivity.
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Key words
AWR,ACTH,CORT,CRF,CRD,EDTA,EMG,HPA,IBS,IκB,IL-1β,MyD88,LPS,NF-κB,PVN,qRT-PCR,TLR4,TNF
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