Influence of encapsulated heat shock protein HSP70 on the basic functional properties of blood phagocytes
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections / translated from Russian(2016)
Abstract
Microencapsulated heat shock proteins HSP 70 were studied in terms of their effects on neutrophil apoptosis, production of reactive oxygen species, and secretion of TNF-α by human neurtrophils and monocytes. Encapsulated HSP70 inhibited neutrophil apoptosis by 65% as compared to the effect of nonencapsulated HSP70; TNF-α production by the promonocytic THP-1 cells was similarly inhibited by the non-encapsulated and encapsulated HSP70. Thus, the polyelectrolyte micromolecules can be used as containers for effective delivery of HSP70 up to neutrophils and monocytes to correct the innate immunity functions.
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Key words
Reactive Oxygen Species Production,Neutrophil Apoptosis,Phagocytic Index,Enhance Reactive Oxygen Species Production,Polyelectrolyte Microcapsule
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