Long term prognostic utility of coronary CT angiography in patients with no modifiable coronary artery disease risk factors: Results from the 5 year follow-up of the CONFIRM International Multicenter Registry.

•In patients without modifiable CAD risk factors, those without CAD by CCTA have a low rate of MACE and all cause mortality.•All cause mortality was predicted by >1 segment of non-obstructive CAD, obstructive 1&2 vessel and 3 vessel/left main CAD.•All-cause mortality demonstrated a dose-response relationship to the severity and number of coronary vessels with CAD.•Presence of non-obstructive and obstructive CAD predicted MACE.