Hepatosplenic T-Cell Lymphoma Mimicking Acute Myeloid Leukemia.
Clinical Lymphoma Myeloma and Leukemia(2016)
摘要
Hepatosplenic T-cell lymphoma (HSTL) is an aggressive non-Hodgkin lymphoma, that usually presents with marked hepatosplenomegaly, systemic symptoms, and often marked thrombocytopenia. HSTL can also be associated with hemophagocytic lymphohistiocytosis. Hepatosplenic T-cell lymphoma has been called "a great clinical imitator," because its clinical features can closely mimic other hematological and/or non-hematological disorders (acute leukemia, autoimmune disorders, systemic infections). In patients with an unusual clinical presentation, the diagnosis of HSTL can only be made by the pathologist who logically integrates the available morphological, immunohistochemical, molecular, and cytogenetic data. The treatment of HSTL is still challenging. Because of its aggressive clinical course, systemic chemotherapy and hematopoietic stem cell transplantation represent the best therapeutic approaches. (C) 2016 Elsevier Inc. All rights reserved.
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关键词
Acute myeloid leukemia,Blast cells,Hemophagocytic lymphohistiocytosis,Integrated diagnosis,Peripheral T-cell lymphoma
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