7,12-Dimethylbenz(a)anthracene-induced genotoxicity on bone marrow cells from mice phenotypically selected for low acute inflammatory response.

Iana Suly Santos Katz,Layra Lucy Albuquerque,Alessandra Paes Suppa,Graziela Batista da Silva,José Ricardo Jensen,Andrea Borrego,Solange Massa,Nancy Starobinas,Wafa Hanna Koury Cabrera,Marcelo De Franco,Primavera Borelli,Olga Martinez Ibañez,Orlando Garcia Ribeiro

DNA Repair（2016）

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摘要

•Mice phenotypically selected for AIR are a good model for PAHs (DMBA) toxicity studies.•AIRmax and AIRmin selected mice present differential susceptibility to DMBA effects.•DMBA treatment induced cell cycle arrest at G1 phase in myeloid cell from AIRmin mice.•AIRmax mice showed a higher capacity of DNA damage repair following DMBA treatment.•AhR gene polymorphism is related with DMBA susceptibility in heterogeneous population.

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关键词

DMBA,Acute inflammatory response,Bone Marrow,DMBA toxicity

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