Examining the connectivity between different cellular processes in the Barrett tissue microenvironment.

•In the Barrett tissue microenvironment, oxidative phosphorylation and p53 status positively correlate with hypoxia.•Oxidative phosphorylation is positively linked to p53 expression whereas levels of glycolysis are negatively associated with p53 expression.•Oxidative phosphorylation and glycolysis are positively associated with inflammation.•Obesity is negatively associated with oxidative phosphorylation but positively associated with glycolysis.•Correlations in ex-vivo Barrett explant tissue demonstrate comparable links between metabolism, p53, hypoxia, inflammation and angiogenesis.