Proliferative Constituents from the Leaves of Micromelum integerrimum.
NATURAL PRODUCT COMMUNICATIONS(2015)
摘要
Two new compounds, 5-O-methyl-4-desmethyl-myricanol (1) and 6-formyl-5-isopropyl-3-hydroxymethyl-7-methyl-1H-indene (2), were isolated from the leaves of Micromelum integerrimum. Their structures were determined by spectroscopic methods. Additionally, compound 1 could stimulate the growth of NIH3T3 cells and promote cell migration. Compound 1 might exert its effects through increasing the protein expression of connective tissue growth factor.
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关键词
Micromelum integerrimum,Diarylheptanoids,Guaiane-type sesquiterpenoid,Proliferative activity,Connective tissue growth factor
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