Evidence for altered osteoclastogenesis in splenocyte cultures from VDR knockout mice.
The Journal of Steroid Biochemistry and Molecular Biology(2018)
摘要
•Vitamin D receptor signalling in the osteoclast lineage is associated with negative regulation of activity.•VDRKO osteoclast-forming cultures expressed highly elevated c-Fos.•Osteoclast number and size from VDRKO splenocyte cultures were reduced compared to wild-type.•VDRKO osteoclast resorptive activity was increased on a per cell basis.
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关键词
Osteoclast,Osteoclastogenesis,Vitamin D,Apoptosis,Vitamin D receptor
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