Molecular mechanism of respiratory syncytial virus fusion inhibitors

Michael B Battles,Johannes P Langedijk,Polina Furmanova-Hollenstein,Supranee Chaiwatpongsakorn,Heather M Costello,Leen Kwanten,Luc Vranckx, Paul Vink,Steffen Jaensch,Tim H M Jonckers,Anil Koul,Eric Arnoult,Mark E Peeples,Dirk Roymans,Jason S McLellan

Nature Chemical Biology（2015）

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摘要

The binding of small-molecule inhibitors of the RSV F glycoprotein in a central cavity in the prefusion conformation stabilizes this conformation and blocks the conformational changes required for fusion with host membranes.

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