Adipocyte progenitor cells initiate monocyte chemoattractant protein-1-mediated macrophage accumulation in visceral adipose tissue.

Jennifer L Kaplan,Melissa A Marshall,Chantel C McSkimming,Daniel B Harmon,James C Garmey,Stephanie N Oldham,Peter T Hallowell,Coleen A McNamara

Molecular Metabolism（2015）

引用 49|浏览9

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摘要

•AdPCs secrete high levels of MCP-1 and promote M1 macrophage accumulation.•HFD increases Id3 to reduce p21Cip1 expression and promote proliferation of AdPCs.•CD44hi AdPCs in visceral adipose tissue express abundant MCP-1.

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关键词

Obesity,MCP-1,Id3,Adipocyte progenitors,Inflammation

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