Association of the Polymorphism in Nucleobindin 2 Gene and the Risk of Metabolic Syndrome.

Objective: Nesfatin-1, originates from the precursor protein nucleobindin 2 (NUCB2) and plays an important role in the development of metabolic syndrome (MetS), including obesity and hypertension. This study aimed to determine whether the 1012C>G polymorphism of NUCB2 gene is correlated with the development of MetS in the Chinese Han population. Materials and Methods: The 1012C>G polymorphism of NUCB2 gene was detected in a population of 326 patients with MetS and 165 healthy subjects. Results: MetS patients showed lower CG and GG genotypes, as well as lower G allele frequencies, compared with healthy subjects. Unconditional logistic regression analysis showed that the GG genotype as well as the G allele were both significantly associated with the decreased risk of developing MetS. In addition, the GG genotype of NUCB2 was significantly correlated with lower levels of waist circumference, body mass index, and fasting plasma glucose in patients with MetS. Conclusions: 1012C>G polymorphism of NUCB2 is correlated with a reduced risk of developing MetS in a Chinese Han population.