Intron retention in mRNA: No longer nonsense: Known and putative roles of intron retention in normal and disease biology.
BIOESSAYS(2016)
Abstract
Until recently, retention of introns in mature mRNAs has been regarded as a consequence of mis-splicing. Intron-retaining transcripts are thought to be non-functional because they are readily degraded by nonsense-mediated decay. However, recent advances in next-generation sequencing technologies have enabled the detection of numerous transcripts that retain introns. As we review herein, intron-retaining mRNAs play an essential conserved role in normal physiology and an emergent role in diverse diseases. Intron retention should no longer be overlooked as a key mechanism that independently reduces gene expression in normal biology. Exploring its contribution to the development and/or maintenance of diseases is of increasing importance.
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Key words
alternative splicing,cancer,gene expression,intron retention,miRNAs,non-coding RNAs,nonsense-mediated decay
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