Prospects of a new antistaphylococcal drug batumin revealed by molecular docking and analysis of the complete genome sequence of the batumin-producer Pseudomonas batumici UCM B-321

International Journal of Antimicrobial Agents(2016)

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摘要
•Batumin acts similarly to mupirocin by targeting aminoacyl tRNA synthetases.•The genome of the batumin-producing strain Pseudomonas batumici was sequenced.•The batumin operon was horizontally acquired together with batG and leuRS paralogues.•The latter genes presumably confer batumin resistance in P. batumici.•Dissimilar batumin/mupirocin resistance mechanisms allow improved MRSA therapy.
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关键词
Antistaphylococcal antibiotic,Pseudomonas batumici,Molecular docking,Genome,Batumin,Mupirocin
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