Practical method development for the separation of monoclonal antibodies and antibody-drug-conjugate species in hydrophobic interaction chromatography, part 1: optimization of the mobile phase.

Marta Rodriguez-Aller,Davy Guillarme,Alain Beck,Szabolcs Fekete

Journal of Pharmaceutical and Biomedical Analysis（2016）

引用 56|浏览7

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摘要

•Numerous variables impacting selectivity and retention in HIC were studied.•Generic experimental design was suggested for method development.•Accurate retention time prediction was feasible.•Applications were developed for mAbs and ADC DARs.

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关键词

Hydrophobic interaction chromatography,Monoclonal antibody,Antibody-drug-conjugate,Method development,Brentuximab-vedotin

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