Accuracy of Hysteroscopic Endomyometrial Biopsy in Diagnosis of Adenomyosis
Journal of Minimally Invasive Gynecology(2016)
摘要
Objectives
To investigate the diagnostic accuracy of endomyometrial biopsy obtained via office hysteroscopy for the diagnosis of adenomyosis.
Study Design
Cross-sectional study.
Setting
Cairo University Teaching Hospital, Cairo, Egypt.
Patients
A total of 404 premenopausal women with symptoms clinically suggestive of having adenomyosis.
Interventions
All patients were subjected to 2-dimensional transvaginal sonography (TVS) in-office hysteroscopy examination with endomyometrial biopsy. Patients who subsequently underwent hysterectomy were included in the final analysis.
Main Measurements and Results
Accuracy of diagnostic modalities was represented using the terms sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy. A total of 292 patients were eligible for final analysis. Of these, 162 (55.47%) were diagnosed with adenomyosis based on hysterectomy specimens. TVS had a high sensitivity (83.95%) and a moderate specificity (60%). In contrast, endomyometrial biopsy was more specific (78.46%) than sensitive (54.32%). Hysteroscopic appearance of the endometrial cavity had low sensitivity (40.74%) and specificity (44.62%). Adding endomyometrial biopsy to TVS improved specificity (89.23%).
Conclusion
Endomyometrial biopsy obtained via office hysteroscopy can diagnose adenomyosis with a high specificity and is recommended after TVS.
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关键词
Adenomyosis,Endomyometrial biopsy,Office hysteroscopy,Sensitivity,Specificity
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