Glycyrrhizin attenuates isoflurane-induced cognitive deficits in neonatal rats via its anti-inflammatory activity.

Wei Wang, Xiaoling Chen,Jie Zhang,Yongshan Zhao,Shusheng Li,L Tan,J Gao, Xianping Fang, An Luo

Neuroscience（2016）

引用 43|浏览6

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摘要

•Glycyrrhizin attenuates isoflurane-induced cognitive deficits in neonatal rats.•Glycyrrhizin alleviates isoflurane-induced hippocampal neuroinflammation.•Isoflurane-induced neuroinflammation is related to the activation of HMGB1/NFκB.•Glycyrrhizin mitigates isoflurane-induced hippocampal apoptosis in neonatal rats.•Glycyrrhizin restores synaptic protein synthesis in neonatal rats.

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AD,EDTA,ELISA,HMGB1,LPS,MWM

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