IL28B gene polymorphisms and Th1/Th2 cytokine levels might be associated with HTLV-associated arthropathy.

Keyla Santos Guedes de Sá,Bárbara Brasil Santana, Tuane Carolina de Souza Ferreira,Rita Catarina Medeiros Sousa,Cezar Augusto Muniz Caldas,Vânia Nakauth Azevedo,Rosimar Neris Martins Feitosa,Luiz Fernando Almeida Machado,Marluísa de Oliveira Guimarães Ishak,Ricardo Ishak,Antonio Carlos Rosário Vallinoto

Cytokine（2016）

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摘要

•Association between HTLV-associated arthropathy (HAA) and IL28B gene was investigated.•Individuals with HAA exhibited low IL-6 and high IL-10 levels.•Genotype TT might be a risk factor for proviral load and CD8+ T cell count.•Genotypes CC and TT seem to be associated with increased TNF-β and IFN-γ levels.

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关键词

HAA,HAM/TSP,HTLV-1,HTLV-2,ISGs,SNPs

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