Non-syndromic cleft lip with or without cleft palate in Asian populations: Association analysis on three gene polymorphisms of the folate pathway.

Marcella Martinelli,Ambra Girardi,Francesca Cura,Nayereh Nouri,Valentina Pinto,Francesco Carinci,Paolo Giovanni Morselli,Mansoor Salehi,Luca Scapoli

Archives of Oral Biology（2016）

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摘要

•The study investigated three candidate genes for cleft lip with or without palate.•The T allele of MTHFR C677T polymorphism reduces the risk of cleft in Asians.•This result conflicts with previous studies.

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关键词

OFC,CL/P,CPO,NSCL/P,MTHFR,TCN2,CBS,SNP,TDT

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