Sevoflurane postconditioning improves long-term learning and memory of neonatal hypoxia-ischemia brain damage rats via the PI3K/Akt-mPTP pathway.

Zhongmeng Lai,Liangcheng Zhang,Jiansheng Su,Dongmiao Cai,Qingxiu Xu

Brain Research（2016）

Cited 60|Views5

No score

Abstract

•Sevoflurane postconditioning protects against hypoxia-ischemia brain damage in rats.•Postconditioning significantly improved long-term cognitive performance of the rats.•Postconditioning increased the number of surviving hippocampal neurons.•The effects of sevoflurane are via PI3K/Akt/eNOS and PI3K/Akt/GSK-3β pathways.•Blockage of mPTP opening may be involved in attenuation of histomorphological injury.

Translated text

Key words

HIBD,mPTP,eNOS,mPTP,Atr,CsA,TTC,Sev,EL,HE,BSA,SD,LSD,PCA

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined