Peripherally Applied Synthetic Tetrapeptides HAEE and RADD Slow Down the Development of Cerebral beta-Amyloidosis in A beta PP/PS1 Transgenic Mice

Two tetrapeptides, HAEE and RADD, which are ionic-complementary to the primary zinc recognition site of amyloid-beta (A beta), have been reported to inhibit zinc-induced dimerization of the A beta metal-binding domain and slow A beta aggregation in vitro. In the present study, we investigate the impact of HAEE and RADD on the development of cerebral beta-amyloidosis in a mouse model of Alzheimer's disease. We have found chronic intravenous administration of each peptide results in significant decrease of amyloid plaque burden in the treated mice.