Role of PUMA in methamphetamine-induced neuronal apoptosis.

Chuanxiang Chen, Litao Qincao,Jingtao Xu,Sihao Du,Enping Huang,Chao Liu,Zhoumeng Lin,Wei-Bing Xie,Huijun Wang

Toxicology Letters（2016）

Cited 35|Views48

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Abstract

•Methamphetamine (METH) exposure increased PUMA protein in PC12 and SH-SY5Y cells.•METH elevated Bax, reduced Bcl-2, activated caspase 3 and PARP.•METH increased the release of cytochrome c from mitochondria to cytoplasm.•All these effects were attenuated or reversed after silencing PUMA with siRNA.

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Key words

Methamphetamine,PUMA (p53 upregulated modulator of apoptosis),Neurotoxicity,Apoptosis

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