Gene expression profiling of bone marrow-derived stromal cells seeded onto a sandblasted, large-grit, acid-etched-treated titanium implant surface: The role of the Wnt pathway.

•19 genes were significantly altered after SLA treatment, including LRP5 and Lect2.•Wnt pathway was the most important signals after SLA treatment.•LRP5 positively regulated SLA-induced enhanced osteogenic differentiation of•BMMSCs.•β-Catenin/LRP5 pathway was responsible for this enhanced osteogenic response.