Spontaneous hypertension occurs with adipose tissue dysfunction in perilipin-1 null mice
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease（2016）
Abstract
Perilipin-1 (Plin1) coats lipid droplets exclusively in adipocytes and regulates two principle functions of adipose tissue, triglyceride storage and hydrolysis, which are disrupted upon Plin1 deficiency. In the present study, we investigated the alterations in systemic metabolites and hormones, vascular function and adipose function in spontaneous hypertensive mice lacking perilipin-1 (Plin1−/−).
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Key words
Perilipin,Hypertension,Perivascular adipose tissue,Oxidative stress,Inflammation
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