Default mode network connectivity is linked to cognitive functioning and CSF Aβ1-42 levels in Alzheimer's disease.
Archives of Gerontology and Geriatrics(2016)
摘要
•Default mode network (DNM) functional connectivity in rest-fMRI is altered in AD.•Cognitive functions are closely linked to DMN functional connectivity changes.•CSF Aβ1–42 level is related to connectivity changes in specific DMN nodes in AD.
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关键词
Alzheimer’s disease,Biomarker,Cognition,Resting functional magnetic resonance imaging,Posterior cingulate cortex,Retrosplenial cortex
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