Default mode network connectivity is linked to cognitive functioning and CSF Aβ1-42 levels in Alzheimer's disease.

Ozlem Celebi,Andac Uzdogan,Kader Karli Oguz,Arzu Ceylan Has,Anil Dolgun,Gul Yalcin Cakmakli,Filiz Akbiyik,Bulent Elibol,Esen Saka

Archives of Gerontology and Geriatrics（2016）

引用 17|浏览64

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摘要

•Default mode network (DNM) functional connectivity in rest-fMRI is altered in AD.•Cognitive functions are closely linked to DMN functional connectivity changes.•CSF Aβ1–42 level is related to connectivity changes in specific DMN nodes in AD.

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关键词

Alzheimer’s disease,Biomarker,Cognition,Resting functional magnetic resonance imaging,Posterior cingulate cortex,Retrosplenial cortex

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