Recurrent inactivating RASA2 mutations in melanoma
NATURE GENETICS(2015)
摘要
Yardena Samuels and colleagues report the analysis of 501 melanoma exomes and the identification of RASA2 as a tumor-suppressor gene mutated in 5% of melanomas. RASA2 mutations led to increased RAS activation, and RASA2 loss was associated with shorter patient survival times.
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关键词
cell biology,functional genomics
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