Identification of the critical attribute(s) of EBV gp350 antigen required for elicitation of a neutralizing antibody response in vivo.

Esteban Servat,Bodrey W Ro,Corinne Cayatte,Lorraine Gemmell,Chris Barton, Eileen Rao,Rui Lin,Fengrong Zuo,Jennifer C Woo,Gregory M Hayes

Vaccine（2015）

引用 19|浏览20

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摘要

•Identification of critical quality attributes for EBV gp350 vaccine development.•Requirement of 72A1 epitope on recombinant gp350 for binding to CD21 on human B cells.•Glycosylation of gp350 is essential for generation of neutralizing antibodies.

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关键词

Epstein–Barr virus,Infectious mononucleosis,Gp350,Vaccine antigen

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