Impact of Alternaria toxins on CYP1A1 expression in different human tumor cells and relevance for genotoxicity.
Toxicology Letters(2016)
Abstract
•CYP1A induction by alternariol is AhR-dependent.•CYP1A induction by alternariol has no substantial impact on genotoxicity.•ATX-II acts as an inducer of CYP1A expression.
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Key words
AhR,AME,AOH,ATX-II,B[a]P,cRNA,CYP1A,DCF,DCFH-DA,DMSO,EROD,MEN,ROS,siRNA,SRB,WST-1
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