mTORC1 and DNA-PKcs as novel molecular determinants of sensitivity to Chk1 inhibition.
Molecular Oncology(2016)
Abstract
•mTOR inhibitors induce synergistic cytotoxicity with V158411.•mTOR inhibition increases V158411 induced DNA DSBs.•Mechanism through regulation of HR and ICL repair proteins by mTOR.•DNA-PKcs overexpressing cells were more sensitive to Chk1 inhibition.•Correlation between CHEK1 and PRKDC (DNA-PKcs) mRNA levels in human tumour samples.
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Key words
Chk1,mTOR,DNA-PKcs,V158411,Double strand break repair
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