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291. Enhanced Therapeutic Effect of Adenoviral Vector-Mediated RTVP-1 Gene Therapy in Combination with Irradiation for Prostate Cancer

Tetsuo Fujita,Koji Naruishi,Nobuyuki Kusaka,Takefumi Satoh,Xiaorong Ji, Jianxiang Wang,Xiaohong Zhu,Guang Yang,Alexei A. Goltsov,Terry L. Timme,Maria T. Vlachaki,Bin S. Teh,E. Brian Butler,Timothy C. Thompson

Molecular Therapy（2004）

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Abstract
Introduction: We previously documented that adenoviral vector-mediated murine RTVP-1 (AdmRTVP-1) gene therapy significantly suppresses the growth of mouse prostate cancer through direct cytotoxicity and the induction of a systemic anti-tumor immune response. This study explores the potential benefits of combining AdmRTVP-1 or adenoviral vector-mediated human RTVP-1 (AdhRTVP-1) gene therapy with irradiation (XRT) to enhance therapeutic efficacy in a subcutaneous prostate cancer model.
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