Assignment of the gene encoding type 1|[gamma]| protein phosphatase catalytic subunit (PPP1CC) on human, rat, and mouse chromosomes

Summary Using fluorescentin situ hybridization (FISH) method, a gene encoding the catalytic subunit of protein phosphatase type 1 ? (PPP1CC) was mapped to human 12q24.1-q24.2, rat 7q22, and mouse 10C. These results indicate that thePPP1CC is a member of conserved synteny group between rat chromosome 7, mouse chromosome 10 and human chromosome 12. These data and mapping data about other members of PP1 family show that in spite of the high identity of PP1 isoforms, each isoform is encoded by different genes which located on different chromosomes in human, rat, and mouse.