785. Synergism of Combined Radiation and Suicide Gene Therapy Using a Chimeric Adenovirus Vector for Bladder Cancer

BACKGROUND: Radiotherapy is an established local therapeutic option for invasive bladder cancer. While radiation leads to membrane damage which may facilitate foreign gene transfer from transduced gene expressing cells to neighboring untransduced cells, cancer cells expressing a cytotoxic gene may not repair radiation induced DNA damage. In addition, radiation may improve gene transduction and transgene integration for gene therapy. In this study, we evaluated the efficacy of a novel CAR independent Ad vector for suicide gene therapy in combination with radiation for bladder cancer in order to determine potential synergism and greater cancer control.