9. Mobilization of Sendai Virus Vectors (SeVV) by Phylogenetic Related Human Pathogens: Implications for Future Vector Generations

Sendai virus as a prototype negative-strand RNA virus vector, keeps to be a promising new gene transfer system in the field of somatic gene therapy. However, future applications require the detailed characterization of safety issues for every new vector system and vector generation. To minimize immune responses and prevent an unrestrained spread of vector sequences, deletions of non-essential genes in the vector backbone are necessary. Therefore, prior to applications in a human setting, this study examined a possible mobilization of single or double gene deleted SeVV by related RNA viruses, being widely distributed as human pathogens.