97 Distribution of Microglia |[lpar]|MG|[rpar]| in the Immature Brain with Isolated Germinal Matrix|[sol]|Intraventricular Haemorrhage |[lpar]|GMH|[sol]|IVH|[rpar]|: A Combined Mri and Histological Approach

Background: GMH/IVH remains a prevalent form of injury to immature brain. In the absence of overt complications, haemorrhage may result in mild ventriculomegaly and poor developmental outcome. The imaging appearances are suggestive of periventicular injury with subsequent tissue atrophy. Although essential for normal brain development, presence of resident MG may exacerbate the injury. We have shown increased activated MG in normally appearing PVWM compared with less susceptible regions. A rabbit model of GMH/IVH demonstrated an increase in activated MG in the adjacent PVWM, which may cause or exacerbate WM injury.