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An in vivo screen identifies ependymoma oncogenes and tumor-suppressor genes

Kumarasamypet M Mohankumar,David S Currle,Elsie White,Nidal Boulos,Jason Dapper,Christopher Eden,Birgit Nimmervoll,Radhika Thiruvenkatam,Michele Connelly,Tanya A Kranenburg,Geoffrey Neale,Scott Olsen,Yong-Dong Wang,David Finkelstein,Karen Wright,Kirti Gupta,David W Ellison,Arzu Onar Thomas,Richard J Gilbertson

NATURE GENETICS（2015）

Cited 59|Views46
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Abstract
Richard Gilbertson and colleagues report an in vivo screen of 84 candidate oncogenes and 39 candidate tumor-suppressor genes in ependymoma mouse models. The validated targets are involved in vesicle trafficking, DNA modification and cholesterol biosynthesis.
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imaging,cell biology
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