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LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control

Jianxun Wang,Francesca Telese,Yuliang Tan, Wenbo Li,Chunyu Jin,Xin He,Harihar Basnet,Qi Ma,Daria Merkurjev,Xiaoyan Zhu,Zhijie Liu,Jie Zhang,Kenny Ohgi,Havilah Taylor,Ryan R White,Cagdas Tazearslan,Yousin Suh,Todd S Macfarlan,Samuel L Pfaff,Michael G Rosenfeld

Nature neuroscience（2015）

Cited 150|Views28
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Abstract
The authors show that the neuron-specific LSD1 variant (LSD1n) promotes transcription initiation and elongation in response to neuronal activity. LSD1n is essential for spatial learning and long-term memory formation. LSD1n exhibits novel substrate specificity for histone H4 K20 methylation.
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Key words
Alternative splicing,Learning and memory,Methylation,Transcription,Biomedicine,general,Neurosciences,Behavioral Sciences,Biological Techniques,Neurobiology,Animal Genetics and Genomics
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