The amylase inhibitor montbretin A reveals a new glycosidase inhibition motif
Nature chemical biology(2015)
Abstract
Montbretin A is a potent inhibitor of amylase, an enzyme critical in starch digestion and thus of relevance for diabetes and obesity. Structural and biochemical analyses now show that a minimal core of the glycoside π-stacks on itself to fit into the active site.
MoreTranslated text
Key words
Enzymes, Dietary carbohydrates, Structure-based drug design, X-ray crystallography
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined