Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog

Daniel T Rogerson,Amit Sachdeva,Kaihang Wang,Tamanna Haq,Agne Kazlauskaite,Susan M Hancock,Nicolas Huguenin-Dezot,Miratul M K Muqit,Andrew M Fry,Richard Bayliss,Jason W Chin

Nature chemical biology（2015）

引用 164|浏览11

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摘要

newly engineered phosphoserine synthetase/tRNA pair allows quantitative insertion of phosphoserine or, when coupled with metabolic rewiring, a non-hydrolyzable analog into protein sequences, leading to high yields of modified constructs for functional analysis.

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nature chemical biology, science

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