Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

Anders Wittrup,Angela Ai,Xing Liu,Peter Hamar,Radiana Trifonova,Klaus Charisse,Muthiah Manoharan,Tomas Kirchhausen,Judy Lieberman

Nature biotechnology（2015）

引用 386|浏览17

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摘要

Live-cell imaging provides new insights in the cytosolic release mechanismsof lipid-formulated siRNAs.

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关键词

Macroautophagy,Oligo delivery,RNAi therapy,Time-lapse imaging,Life Sciences,general,Biotechnology,Biomedicine,Agriculture,Biomedical Engineering/Biotechnology,Bioinformatics

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