Characterization of substrate binding of the WW domains in human WWP2 protein.

Jiahong Jiang,Nan Wang,Yafei Jiang,Hongwei Tan,Jimin Zheng,Guangju Chen,Zongchao Jia

FEBS Letters（2015）

Cited 5|Views11

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Abstract

•Human WWP2 binds PPXY motif substrates only via WW domains.•WW domains bind substrate in a priority dependent manner, displaying a novel direct binding mode.•Modeled WW domain structure substantiated by results in alanine scanning.

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Key words

WWP2,IPTG,SDS–PAGE,SPR,ITC,MD

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