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Identification of MK-8133: an Orexin-2 Selective Receptor Antagonist with Favorable Development Properties.

Scott D. Kuduk,Jason W. Skudlarek, Christina N. DiMarco,Joseph G. Bruno,Mark H. Pausch,Julie A. O'Brien,Tamara D. Cabalu,Joanne Stevens,Joseph Brunner,Pamela L. Tannenbaum,Susan L. Garson,Alan T. Savitz,Charles M. Harrell,Anthony L. Gotter,Christopher J. Winrow,John J. Renger,Paul J. Coleman

Bioorganic & Medicinal Chemistry Letters（2015）

Cited 19|Views34

Key words

Orexin,Insomnia,GPCR,Antagonist,Sleep

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