PTX3 Polymorphisms and Invasive Mold Infections After Solid Organ Transplant.

Agnieszka Wojtowicz,T Doco Lecompte,Stephanie Bibert,Oriol Manuel,Sina Rueger,Christoph Berger,K Boggian,A Cusini,Christian Garzoni,Nina Khanna,Nicolas J Mueller,Pascal R Meylan,Manuel Pascual,Christian Van Delden,Pierreyves Bochud,Rita Achermann,Johndavid Aubert,Philippe Baumann,Guido Beldi,Christian Benden,Isabelle Binet,Elsa Boely,Heiner C Bucher,L Buhler,Thierry Carell,Emmanuelle Catana,Yves Chalandon,Sabina De Geest,Olivier De Rougemont,Michael Dickenmann,Michel A Duchosal,Thomas Fehr,Sylvie Ferrarilacraz,Yvan Gasche,Paola Gasche Soccal,Emiliano Giostra,Dela Golshayan,Daniel Good,Karine Hadaya,Christoph Hess,Sven Hillinger,Hans H Hirsch,Gunther F L Hofbauer,Uyen Huynhdo,Franz F Immer,Richard Klaghofer,Michael Koller,Thomas Kuntzen,Bettina Laesser,Roger Lehmann,Christian Lovis,Hanspeter Marti,P Y Martin,Paul Mohacsi,Isabelle Morard,Philippe Morel,Ulrike Mueller,Helen Muellermckenna,Thomas Muller,Beat Mullhaupt,David Nadal,Gayathri Nair,Jakob Passweg, Chantal Piot Ziegler,Juliane Rick,Eddy Roosnek,Anne Rosselet,Silvia Rothlin,Frank Ruschitzka,Urs Schanz,Stefan Schaub,Christian Seiler,Nasser Semmo,Susanne Stampf,Jurg Steiger,Christian Toso,Dimitri Tsinalis, J P Venetz,Jean Villard,Madeleine Wick,M Wilhelm,Patrick Yerly

CLINICAL INFECTIOUS DISEASES（2015）

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摘要

Donor PTX3 polymorphisms were shown to influence the risk of invasive aspergillosis among hematopoietic stem cell transplant recipients. Here, we show that PTX3 polymorphisms are independent risk factors for invasive mold infections among 1101 solid organ transplant recipients, thereby strengthening their role in mold infection pathogenesis and patients' risk stratification.

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关键词

innate immunity,SNP,PTX3,genetic susceptibility,solid organ transplant

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