Post-translational modification of a chimeric EPO-Fc hormone is more important than its molecular size in defining its in vivo hematopoietic activity.
Biochimica et Biophysica Acta (BBA) - General Subjects(2015)
Abstract
•Mammary gland adenoviral transduction is a robust methodology for protein expression.•A sialylated N-glycans profile defines the hematopoietic activity of EPO-Fc variants.•Goat mammary cells aren't a proper system for the active glyco-hormones expression.
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Key words
Erythropoietin,Adenovirus vector,N-glycans,Mammary epithelial cell,Milk expression,Hematopoietic activity
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